Groundbreaking research claims to have "rejuvenated" human eggs by reversing an age-related defect that causes genetic errors in embryos, potentially revolutionizing IVF success rates for older women. The study found that supplementing donated eggs with a crucial protein, Shugoshin 1, can nearly halve the number of eggs with abnormal chromosome numbers.
The decline in egg quality is the primary cause of IVF failure and miscarriage in older women, resulting in significantly lower birth rates as female age increases. For example, for women under 35, the average birth rate per embryo transferred in IVF treatment was 35%, while it dropped to just 5% for women aged 43-44.
According to researchers, this age-related defect occurs during meiosis, a process where sex cells jettison half their genetic material. In eggs, this requires 23 pairs of X-shaped chromosomes to align along a single axis in the cell. However, in older eggs, chromosome pairs tend to loosen at their midpoint, becoming slightly unstuck or detaching entirely before fertilization.
The team found that microinjections of Shugoshin 1 reversed this problem by restoring the protein levels in treated eggs to those seen in younger cells. This resulted in a significant decrease in the number of eggs with defective chromosomes. The researchers estimate that this approach could improve egg quality, leading to better IVF success rates and reduced risk of chromosome disorders such as Down's syndrome.
While the findings are promising, it is essential to note that the approach would not extend fertility beyond menopause, when the egg reserve runs out. However, if successful in larger trials, this technique has the potential to significantly improve IVF outcomes for older women.
The decline in egg quality is the primary cause of IVF failure and miscarriage in older women, resulting in significantly lower birth rates as female age increases. For example, for women under 35, the average birth rate per embryo transferred in IVF treatment was 35%, while it dropped to just 5% for women aged 43-44.
According to researchers, this age-related defect occurs during meiosis, a process where sex cells jettison half their genetic material. In eggs, this requires 23 pairs of X-shaped chromosomes to align along a single axis in the cell. However, in older eggs, chromosome pairs tend to loosen at their midpoint, becoming slightly unstuck or detaching entirely before fertilization.
The team found that microinjections of Shugoshin 1 reversed this problem by restoring the protein levels in treated eggs to those seen in younger cells. This resulted in a significant decrease in the number of eggs with defective chromosomes. The researchers estimate that this approach could improve egg quality, leading to better IVF success rates and reduced risk of chromosome disorders such as Down's syndrome.
While the findings are promising, it is essential to note that the approach would not extend fertility beyond menopause, when the egg reserve runs out. However, if successful in larger trials, this technique has the potential to significantly improve IVF outcomes for older women.
just read about some crazy research on rejuvenating human eggs... basically they found a protein that can fix age-related genetic errors in embryos lol what would've been 35% chance of getting pregnant at 35 now might be like 50-60% at 43 
but still, gotta remember this is just lab research for now so not all hope yet 
. They're trying to sell us on this Shugoshin 1 protein like it's a miracle cure, but what's really going on? Who funded this study and why? It's not just a coincidence that they chose an age-related defect that affects women of childbearing age. Maybe there's more to this protein than meets the eye... 
And let's be real, if they can reverse this issue in eggs, do you think it'll come with some kind of side effect or agenda? 
We need to keep a close eye on this one 
.
OMG I'm so hyped about this research!!! It's like a total game changer for women over 35 who want to have kids! 
The idea that they can basically 'rejuvenate' their eggs is mind blowing! 
And can you even imagine how much of a difference this could make in IVF success rates? It's crazy to think that something as simple as supplementing donated eggs with Shugoshin 1 protein could almost halve the number of eggs with chromosomal errors. 
The implications are huge and I'm literally crossing my fingers for the future! 
I mean think about it, they're basically bringing back the youthful chromosomes from those donated eggs and injecting it into the older eggs... it's like a genetic reboot 
what if this opens doors to something bigger tho? like, could this be a way for ppl to 'hack' their own DNA or reverse some kind of natural aging process? 
. basically, what they did was give treated eggs a protein called Shugoshin 1 that helps them get their genetic material all lined up and stuff 
. now, we're talking nearly half fewer eggs with abnormal chromosomes 
. could be huge for women who are trying to conceive later in life 
I mean, isn't it about time someone figured out how to fix the whole "you get drier and more fragile with age" thing? Like, who doesn't want a decent chance at having kids in their 40s? The fact that researchers have finally stumbled upon this protein, Shugoshin 1, is kinda impressive, I guess. 
Also, I wonder how many women will be able to afford this... 
. I'm sure many people are wondering if this means there's a way to extend fertility beyond menopause... but it's also important to keep things realistic and note that the approach wouldn't be able to overcome the natural decline in egg quality 
This study sounds like a total game-changer for older women trying to conceive! I mean, who wouldn't want to have more control over their family planning? It's crazy that it comes down to something as simple as a protein supplement to fix the egg's chromosome problem 
. Of course, there are caveats - like the fact that menopause is still a hard limit 
Still, if it can reduce the risk of chromosome disorders and stuff like Down's syndrome, that's a huge win in my book. And hey, maybe this means we'll see more women trying for kids later on in life? 
. I mean, don't get me wrong, it's awesome that they're trying to crack the code on egg quality, but this Shugoshin 1 protein thing sounds like just another Band-Aid solution 
The more I think about it, the more I'm convinced we need to be looking at more holistic approaches to fertility... or just invest in better IVF tech 
It's like they're giving old eggs a new lease on life 
. I mean, think about it - if they can just fix the problem with chromosome numbers, IVF success rates for older women would go through the roof 
. This could be like, a game changer? 
but seriously, this protein Shugoshin 1 sounds like a game changer 
can't wait to see more research on this one 
hope it works out for all those women tryin to start fams at older ages 
. And now they're saying this new approach could basically halve the number of eggs with genetic errors 
. I don’t know what the future holds but if this works out, it could be a game-changer 
.
It's like a dream come true for all those women who wanna be moms, but are worried 'cause of their age 
. It's like, we knew it was gonna be a protein or something, but to actually find one that can fix this genetic error is huge 
.