Lithium levels in drinking water may be linked to an increased risk of autism spectrum disorder (ASD) in children, according to a new study published in the journal JAMA Pediatrics. The research found a modest association between lithium exposure and ASD diagnosis in Denmark, where the levels of lithium in tap water are similar to those in US water systems.
The study analyzed data from 8,842 cases of ASD and 43,864 participants who did not have ASD, and found that as lithium levels in water increased, so did the risk of an ASD diagnosis. Specifically, children born to pregnant women exposed to high levels of lithium had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure.
However, experts caution that this association does not necessarily mean that lithium exposure leads directly to an autism diagnosis. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, a study co-author and professor at UCLA. Further research is needed to understand whether there is a causal link between lithium exposure and ASD.
The implications of this finding are complex, as some studies have suggested connections between ASD and environmental exposures to things like pesticides, air pollution, and phthalates. However, none of these factors have been shown to be directly causally linked to the disorder.
"It's an interesting association," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "But causation is definitely not proven. We need to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
Dr. Wiznitzer noted that other studies have suggested connections between ASD and environmental exposures, but these findings are often difficult to prove due to the complexity of the disorder. "We're bombarded with a variety of environmental stressors in our everyday lives," he said. "We need to figure out how to safely navigate them."
The study's findings highlight the importance of monitoring drinking water quality and studying the potential effects of environmental contaminants on human health. As Dr. Ritz noted, further research is needed to understand whether lithium exposure contributes to the development of ASD.
The study analyzed data from 8,842 cases of ASD and 43,864 participants who did not have ASD, and found that as lithium levels in water increased, so did the risk of an ASD diagnosis. Specifically, children born to pregnant women exposed to high levels of lithium had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure.
However, experts caution that this association does not necessarily mean that lithium exposure leads directly to an autism diagnosis. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, a study co-author and professor at UCLA. Further research is needed to understand whether there is a causal link between lithium exposure and ASD.
The implications of this finding are complex, as some studies have suggested connections between ASD and environmental exposures to things like pesticides, air pollution, and phthalates. However, none of these factors have been shown to be directly causally linked to the disorder.
"It's an interesting association," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "But causation is definitely not proven. We need to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
Dr. Wiznitzer noted that other studies have suggested connections between ASD and environmental exposures, but these findings are often difficult to prove due to the complexity of the disorder. "We're bombarded with a variety of environmental stressors in our everyday lives," he said. "We need to figure out how to safely navigate them."
The study's findings highlight the importance of monitoring drinking water quality and studying the potential effects of environmental contaminants on human health. As Dr. Ritz noted, further research is needed to understand whether lithium exposure contributes to the development of ASD.