New Gene Therapy Successfully Cuts Cholesterol Levels in Half, Bringing Hope for Heart Disease Treatment
A groundbreaking study published in The New England Journal of Medicine has shown that a gene-editing therapy developed by Swiss biotech company Crispr Therapeutics can slash high cholesterol levels in half. In a small but promising trial conducted between June and August 2025, 15 participants received a one-time infusion of the treatment, which targets the liver's production of cholesterol.
The study found that the highest dose tested reduced both "bad" LDL cholesterol and triglycerides by an average of 50 percent within two weeks after treatment. The effects lasted at least 60 days, a duration longer than previously seen in gene-editing trials. The results have sparked excitement among medical experts, who believe this therapy could be a game-changer for treating common conditions like heart disease.
The study's lead author, Steven Nissen, an expert from the Heart, Vascular and Thoracic Institute at Cleveland Clinic, stated that "these are very sick people" participating in the trial. Their condition often results in premature death or disability, but with this therapy, it's possible to potentially reverse the trajectory of their disease.
However, safety concerns remain a key issue for new gene-editing therapies, which can cause liver damage as a known risk. Researchers are working to address these concerns and conduct further trials to confirm efficacy and safety. Phase II studies are planned for 2026 with an expanded patient population and longer follow-up period.
While the trial's findings are promising, it's essential to note that one participant died six months after receiving the lowest dose of the treatment due to their underlying heart disease rather than the experimental therapy itself. Nonetheless, if future trials confirm safety and efficacy, this therapy could revolutionize the way we treat cardiovascular diseases, particularly at an earlier stage.
The potential for gene-editing therapies in treating common conditions is vast, and this study brings hope for patients suffering from high cholesterol and heart disease. As research continues to unfold, it's crucial to closely monitor the development of these treatments and their impact on public health.
A groundbreaking study published in The New England Journal of Medicine has shown that a gene-editing therapy developed by Swiss biotech company Crispr Therapeutics can slash high cholesterol levels in half. In a small but promising trial conducted between June and August 2025, 15 participants received a one-time infusion of the treatment, which targets the liver's production of cholesterol.
The study found that the highest dose tested reduced both "bad" LDL cholesterol and triglycerides by an average of 50 percent within two weeks after treatment. The effects lasted at least 60 days, a duration longer than previously seen in gene-editing trials. The results have sparked excitement among medical experts, who believe this therapy could be a game-changer for treating common conditions like heart disease.
The study's lead author, Steven Nissen, an expert from the Heart, Vascular and Thoracic Institute at Cleveland Clinic, stated that "these are very sick people" participating in the trial. Their condition often results in premature death or disability, but with this therapy, it's possible to potentially reverse the trajectory of their disease.
However, safety concerns remain a key issue for new gene-editing therapies, which can cause liver damage as a known risk. Researchers are working to address these concerns and conduct further trials to confirm efficacy and safety. Phase II studies are planned for 2026 with an expanded patient population and longer follow-up period.
While the trial's findings are promising, it's essential to note that one participant died six months after receiving the lowest dose of the treatment due to their underlying heart disease rather than the experimental therapy itself. Nonetheless, if future trials confirm safety and efficacy, this therapy could revolutionize the way we treat cardiovascular diseases, particularly at an earlier stage.
The potential for gene-editing therapies in treating common conditions is vast, and this study brings hope for patients suffering from high cholesterol and heart disease. As research continues to unfold, it's crucial to closely monitor the development of these treatments and their impact on public health.
Oh man, I just saw that a study was published about some new gene therapy that can cut cholesterol levels in half... but let's be real, we've heard that promise before and it always seems to get watered down by safety concerns 
. Like, yeah, the researchers are working on addressing those risks, but what about the one person who died six months after getting the treatment? That's not exactly reassuring 
. And don't even get me started on the trial being so small... 15 participants is basically a tiny sample size 
. I'm sure there will be plenty of follow-up trials and more info comes out, but until then, let's keep our expectations in check 
.
I cant even handle how amazing this new gene therapy is!!!!! 
They're literally cutting cholesterol levels in HALF with a one-time infusion!!! 
Those poor ppl need all the hope they can get and this study brings it 
And yeah, safety concerns are valid but if they can address those then this could be LIFE CHANGING!!! 
The fact that 1 participant died 6 months after the trial is a major concern tho 
But if future trials confirm the efficacy and safety then we're talking REVOLUTIONARY MEDICINE here!!! 
We need more research ASAP so we can get these treatments to ppl who desperately need them 
It's like, finally some real hope for people struggling with high cholesterol and heart disease 
. I mean, 50% reduction in cholesterol levels in just two weeks? That's insane 
.
. We need more of these kinds of breakthroughs ASAP 
.
. If it works out, we could be looking at a whole new paradigm for treating cardiovascular diseases 
Oh man, can you imagine your body being like "peace out, I'm cutting back on all that cholesterol" 
after a one-time infusion? Sounds like a magic solution for heart disease! 
But seriously, 50% less cholesterol in just two weeks? That's like me gaining 10 pounds of weight (just kidding, sorta) 
. still, if they can make it safe & effective, it cud b a total game-changer 
idk why they're making such a big deal about cutting cholesterol levels in half. like, isn't 50% a pretty low bar? 
also, i'm not sure if i'd wanna be one of the lucky ones who gets to try this out... sounds kinda intense 
and yeah, safety concerns are legit... can't have people dropping dead mid-trial due to experimental therapy 
anyway, glad someone's working on it? 
This is such a game-changer! Reducing cholesterol levels by half in just two weeks sounds almost too good to be true 
. Still, I'm hopeful that Crispr Therapeutics will be able to address those concerns and get this treatment out there ASAP 
. I just hope we don't lose sight of the fact that these treatments are for people who need them most – patients who have already been affected by heart disease, or in some cases, those who might not even get a chance to try this treatment if it's not approved 
. We gotta keep pushing for better healthcare for all! 
gotta say, though, the safety concerns are valid - we can't just ignore the risk of liver damage. but if they can figure out how to make it safe & effective... watch out world! 
... all we gotta do is make some informed choices and take care of ourselves, eat healthier, exercise more, don't smoke, etc. 
... anyway, this study brings hope, so let's keep the faith and support these researchers who are working tirelessly to make a difference 
And the effects lasted at least 60 days, which is insane! 
This could be a total paradigm shift for treating heart disease and premature death 
#HeartDiseaseTreatment #GeneEditingTherapy
, can u imagine having a therapy that literally cuts ur cholesterol levels in half? 
. We need to keep monitoring these treatments and make sure they're safe for everyone 
! It's like Doctor Foster from The Good Doctor 
"We were built to fall in love, but now we're breaking through"...
crispr tech is getting better tho, hope it continues to improve and we see more promising results soon 