Scientists in Germany claim to have developed a nasal vaccine that can effectively combat Covid-19 by targeting the point where the virus enters the body. The vaccine, which uses a weakened form of the coronavirus, has shown promising results in hamster studies, with two doses demonstrating "sterilizing immunity" and preventing illness.
The new approach focuses on boosting mucosal immunity, specifically in the tissues that line the upper airways. Researchers believe this method can provide long-lasting protection against future variants of the virus. According to study author Emanuel Wyler, the vaccine works like having firefighters stationed at the smoke alarm, quickly responding to any potential threats.
Unlike traditional vaccines that primarily target blood-borne viruses, mucosal vaccines aim to prime immune cells in the nasal tissues. This allows for a more rapid and effective response when infected with the virus. Wyler notes that this approach can potentially be more effective against new variants of the coronavirus, as it doesn't rely solely on spike protein antibodies like current vaccines.
In hamster studies, the vaccine outperformed traditional mRNA-based and adenovirus-based vaccines, demonstrating its potential to prevent illness. However, experts caution that more research is needed before human trials can begin, particularly to address concerns about immune memory and variant susceptibility.
At least four nasal vaccines for Covid-19 have reached late-stage testing in humans, according to the World Health Organization. While other vaccines like those developed by China and India have been approved, their effectiveness data remains uncertain. The German team is eager to see results from a rival vaccine being tested in South America and Africa later this year.
Respiratory infections can be challenging targets for inhalable vaccines, with past examples like FluMist showing mixed results in adults. Nevertheless, the concept of using live attenuated viruses has proven effective for certain vaccines, such as those against measles, mumps, and rubella.
Care must be taken when developing live vaccines due to concerns about compromised immunity individuals. Even weakened viruses can pose risks, making it essential to use these vaccines with caution.
The new approach focuses on boosting mucosal immunity, specifically in the tissues that line the upper airways. Researchers believe this method can provide long-lasting protection against future variants of the virus. According to study author Emanuel Wyler, the vaccine works like having firefighters stationed at the smoke alarm, quickly responding to any potential threats.
Unlike traditional vaccines that primarily target blood-borne viruses, mucosal vaccines aim to prime immune cells in the nasal tissues. This allows for a more rapid and effective response when infected with the virus. Wyler notes that this approach can potentially be more effective against new variants of the coronavirus, as it doesn't rely solely on spike protein antibodies like current vaccines.
In hamster studies, the vaccine outperformed traditional mRNA-based and adenovirus-based vaccines, demonstrating its potential to prevent illness. However, experts caution that more research is needed before human trials can begin, particularly to address concerns about immune memory and variant susceptibility.
At least four nasal vaccines for Covid-19 have reached late-stage testing in humans, according to the World Health Organization. While other vaccines like those developed by China and India have been approved, their effectiveness data remains uncertain. The German team is eager to see results from a rival vaccine being tested in South America and Africa later this year.
Respiratory infections can be challenging targets for inhalable vaccines, with past examples like FluMist showing mixed results in adults. Nevertheless, the concept of using live attenuated viruses has proven effective for certain vaccines, such as those against measles, mumps, and rubella.
Care must be taken when developing live vaccines due to concerns about compromised immunity individuals. Even weakened viruses can pose risks, making it essential to use these vaccines with caution.
that can combat Covid-19. The idea of boosting mucosal immunity is so cool 
! I've been hearing that this approach can provide long-lasting protection against future variants of the virus, which would be a total game-changer 
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It's crazy how much research went into developing these vaccines. The concept of using live attenuated viruses has proven effective for other vaccines, so I have no doubt that this one will too 
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. Immune memory and variant susceptibility are major concerns, so let's hope scientists can iron those out soon 
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. Bring on the progress! 
Like, just imagine getting a shot and then suddenly you're the hero of your own respiratory system. It's all about those mucosal immunity tissues, huh? The researchers are trying to prime immune cells, but I'm pretty sure my grandma could do that with some TLC and a good dose of skepticism. Seriously though, it's interesting that this approach might be more effective against new variants. We'll just have to wait and see how it plays out in human trials. Hopefully, it won't be like FluMist... 
and I gotta say, its a game changer 
especially if it can provide long-lasting protection against future variants of covid-19 
its like having a fire alarm that quickly responds to threats 
rather than relying on blood-borne viruses which is super slow 
hopefully more research comes out and it gets tested on humans soon 
I think this is a great step forward in Covid-19 research! A nasal vaccine targeting the virus's entry point could be super effective against future variants 
What I'd love to see next is more human trials and results from those 
#NasalVaccine #Covid19Research #ImmunityBoost
. And the best part? This approach might just provide long-lasting protection against future variants, which is like having an insurance policy against the virus 
. I'm not surprised it outperformed traditional vaccines in those hamster studies - this technology is so smart 
!
Another Covid-19 vaccine comes along but let's keep things realistic here... a new German nasal vaccine is looking promising in hamster studies 
, but we're still talking about animal trials. We need to see some human trials before getting our hopes up 
. I'm not saying it's a bad idea or anything, but let's not get ahead of ourselves here... we've been down this road before with other Covid-19 vaccines and they didn't exactly go as planned 
. And to make matters worse, at least four more nasal vaccines are already in late-stage testing, which just increases the chances that one of them might not work out either 
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... I guess that's the trade-off we have to make when developing new vaccines 
... do we prioritize effectiveness or safety? 
- it's so easy to understand how this vaccine would work! 
And I agree, traditional vaccines that focus on blood-borne viruses aren't as effective against new variants of Covid-19 
. The fact that they outperformed other vaccines in hamster studies is a big deal 
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. I'm excited to see how it pans out and if it can provide long-lasting protection against future variants 
. It's also worth noting that if we can develop a vaccine that doesn't rely on just one type of antibody, we might be able to tackle those tricky variant problems more effectively 
...and let's not forget the potential risks with live attenuated viruses 
. Just hope they do more research and make sure it's safe for humans too 
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they should just do more research in hamsters or something before testing it on humans 
and yeah the flu mist example was a fail 
can't believe they didn't think that one through lol anyway, fingers crossed it works out this time 
! I mean, think about it, targeting the point where the virus enters the body makes total sense 
. This could be a game changer in the fight against Covid-19 
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. And let's be real, who wouldn't want a vaccine that could potentially provide long-lasting protection against future variants of the virus? 
