Lithium levels in tap water may be linked to an increased risk of autism spectrum disorder (ASD) in children, according to a new study. The research, published in the journal JAMA Pediatrics, found that higher concentrations of lithium in drinking water were associated with a modestly elevated risk of ASD diagnosis.
The study's findings are based on data from Denmark, where researchers analyzed the concentration of lithium in public waterworks and mapped out where pregnant people lived. They found that as lithium levels in water increased, so did the risk of an ASD diagnosis among children born to those women.
However, experts caution that the association between lithium exposure and ASD is not direct. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, co-author of the study. But she added that further research is needed to confirm the findings and rule out confounding variables.
The implications of the study's findings are complex, particularly for public health policy. While higher lithium levels in water have been linked to improved outcomes for certain psychiatric disorders, such as lower rates of hospitalization for mental illness and suicide, the risks associated with ASD remain unclear.
Other studies have suggested connections between environmental exposures and ASD, including air pollution and pesticides. However, these findings are often based on associations rather than direct causation, which can be difficult to prove.
"We need to figure out how to safely navigate these environmental stressors," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "The relationship between lithium exposure and ASD is interesting, but we need more research to confirm it."
In light of the study's findings, some experts are calling for greater regulation of lithium levels in drinking water. "If all these associations are valid, the wisdom of Solomon will be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population," wrote Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School.
Ultimately, more research is needed to understand the relationship between lithium exposure and ASD. While the study's findings are intriguing, they should be viewed with caution until further evidence is gathered.
The study's findings are based on data from Denmark, where researchers analyzed the concentration of lithium in public waterworks and mapped out where pregnant people lived. They found that as lithium levels in water increased, so did the risk of an ASD diagnosis among children born to those women.
However, experts caution that the association between lithium exposure and ASD is not direct. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, co-author of the study. But she added that further research is needed to confirm the findings and rule out confounding variables.
The implications of the study's findings are complex, particularly for public health policy. While higher lithium levels in water have been linked to improved outcomes for certain psychiatric disorders, such as lower rates of hospitalization for mental illness and suicide, the risks associated with ASD remain unclear.
Other studies have suggested connections between environmental exposures and ASD, including air pollution and pesticides. However, these findings are often based on associations rather than direct causation, which can be difficult to prove.
"We need to figure out how to safely navigate these environmental stressors," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "The relationship between lithium exposure and ASD is interesting, but we need more research to confirm it."
In light of the study's findings, some experts are calling for greater regulation of lithium levels in drinking water. "If all these associations are valid, the wisdom of Solomon will be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population," wrote Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School.
Ultimately, more research is needed to understand the relationship between lithium exposure and ASD. While the study's findings are intriguing, they should be viewed with caution until further evidence is gathered.